Jian Liu

This study identifies SMAD4 as a regulator of 3D genome architecture in lung squamous cell carcinoma, showing its role in inhibiting tumor development by constraining chromatin looping.

This study identifies a polyclonal-to-monoclonal evolutionary trajectory in lung squamous cell carcinoma using genomic and transcriptomic data, with implications for precision therapeutics.

This study identifies key residues in McdB that modulate its interaction with McdA, revealing distinct roles for weak and strong interactions in carboxysome positioning and partitioning.

The paper tracks single mRNA translation in live cells, revealing that translation occurs in bursts and is influenced by 5' UTR structure and environmental signals.

The paper shows that Dynamin 1xA forms molecular condensates with Syndapin 1 at endocytic sites, enabling ultrafast endocytosis by bypassing the recruitment step.

The paper shows that Dynamin 1xA and Syndapin 1 form liquid-like condensates at synapses, which facilitate ultrafast endocytosis by enabling molecular crowding and intermolecular interactions.

LungCancer3D integrates HiC with multi-omics data to visualize lung cancer chromatin architecture and gene regulation mechanisms.