Author

Alicia Xu

Brotman Baty InstituteORCID 0009-0001-9766-3622Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Genetic & Genomic Medicine· 1 Genomics· 1

Signature Assays, Organisms & Methods

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Organism:human· 2 Research Focus:variant effect prediction· 2 Assay:whole-exome sequencing· 2 Approach:experimental assay· 1 Approach:statistical model· 1

Frequent Co-Authors

Abbye E. McEweniD· 2 shared Airi HosokaiiD· 2 shared Douglas M. FowleriD· 2 shared Ivan M. H. WooiD· 2 shared Lara A. MuffleyiD· 2 shared Lea M. StaritaiD· 2 shared Malvika TejuraiD· 2 shared Matthew W. SnyderiD· 2 shared

Activity by Year

2025-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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2 shared papersGenomics

Abbye E. McEwenORCID

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2 papers

Recent·Most cited

GenomicsbioRxivPreprintFeb 23, 2026

A scalable approach to resolving variants of uncertain significance

Malvika Tejura, Y P Chen, Abbye E. McEwen…·Lea M. Starita

The paper develops a scalable workflow to reclassify variants of uncertain significance using experimental and predictive evidence, resolving 75% of VUS in 40 genes.

4 citations

humanwhole-exome sequencing

𝕏 PostBluesky

Genetic & Genomic MedicinemedRxivPreprintNov 3, 2025

Saturation genome editing of BARD1 resolves VUS and provides insight into BRCA1-BARD1 tumor suppression

Ivan M. H. Woo, Silvia Casadei, Matthew W. Snyder…·Lea M. Starita

The paper uses saturation genome editing to evaluate BARD1 variants, resolving most variants of uncertain significance and confirming their role in tumor suppression.

4 citations

humanwhole-exome sequencing

𝕏 PostBluesky