Author

Alexander Spektor

Harvard UniversityORCID 0000-0002-1085-3205Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Cancer Biology· 2 Biochemistry· 1 Cell Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:human· 3 Assay:proteomics· 2 Approach:biophysical modeling· 1 Assay:bulk RNA-seq· 1 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1

Frequent Co-Authors

Dipanjan ChowdhuryiD· 2 shared Albino BacollaiD· 1 shared Aleem SyediD· 1 shared Amy Verway-CoheniD· 1 shared Andrew S. Arvai· 1 shared Andrew T. BockusiD· 1 shared Aniruddha Sarkar· 1 shared Aniruddha SarkariD· 1 shared

Activity by Year

2025-2026 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 16 mutual co-author links

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2 shared papersCell Biology

Dipanjan ChowdhuryORCID

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

The TIRR-53BP1 axis controls PLK1 spatiotemporal regulation during mitosis

Aniruddha Sarkar, Shrabasti Roychoudhury, Katherine N. Choe, Neil T. Umbreit, H. Rudolf de Boer, Yizhou Joseph He, Bartłomiej Tomasik, Marcel A.T.M. van Vugt, David S. Pellman, Dipanjan Chowdhury, Alexander Spektor

This study shows that the TIRR-53BP1 axis regulates PLK1 activity during mitosis, affecting chromosome segregation and kinetochore assembly.

bioRxiv · Jun 30, 2026 · PreprintCell Biology

Synergistic targeting of MCL1 and caspases for enhanced anti-tumor immunity in breast cancer.

Jae Kyo Yi, Jisun Lee, Pilhan Kim, Leslie M. Shaw, Alexander Spektor

This study shows that combining MCL1 and caspase inhibition enhances anti-tumor immunity in breast cancer by activating the cGAS-STING pathway and remodeling the tumor microenvironment.

bioRxiv · Oct 10, 2025 · PreprintCancer Biology

Human CDK5-cyclin B1 structures uncover a conserved mitotic CDK activation mechanism

Andrew S. Arvai, Ke Cong, Xiao-Feng Zheng, Amy Verway-Cohen, Miaw-Sheue Tsai, Huy Q. Nguyen, Albino Bacolla, Chi-Lin Tsai, George A. Lantz, Alexander Spektor, Dipanjan Chowdhury, John A. Tainer, Aleem Syed

The paper determines the first high-resolution crystal structures of CDK5-cyclin B1, revealing its mitotic activation mechanism similar to CDK1-cyclin B1.

bioRxiv · Sep 10, 2025 · PreprintBiochemistry

Cyclin A/B RxL Macrocyclic Inhibitors to Treat Cancers with High E2F Activity

Shilpa Singh, Catherine E. Gleason, Min Fang, Yasmin Nabil Laimon, Vishal Khivansara, Shanhai Xie, Yavuz T. Durmaz, Aniruddha Sarkar, Kenneth H. Ngo, Varunika Savla, Yixiang Li, Muhannad Abu‐Remaileh, Xinyue Li, Marie-Anaïs Locquet, Bishma Tuladhar, , Matthew G. Oser

This paper develops cyclin A/B macrocyclic inhibitors that induce apoptosis in cancers with high E2F activity by blocking RxL-mediated interactions, showing efficacy in SCLC models.

Journal of Thoracic Oncology · Aug 1, 2025Peer-reviewedCancer Biology