Author

Shilpa Singh

Brigham and Women's HospitalORCID 0000-0002-2648-2621Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:genetic perturbation / CRISPR· 2 Organism:human· 2 Approach:benchmark study· 1 Assay:bulk RNA-seq· 1 Research Focus:cancer & tumor microenvironment· 1 Research Focus:drug response / drug discovery· 1 Approach:experimental assay· 1 Assay:proteomics· 1

Frequent Co-Authors

John G. DoenchiD· 2 shared Matthew G. OseriD· 2 shared Xinyue LiiD· 2 shared Yixiang LiiD· 2 shared Alexander SpektoriD· 1 shared Alexander Wang YingiD· 1 shared Andrew T. BockusiD· 1 shared Aniruddha SarkariD· 1 shared

Activity by Year

2024-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 37 mutual co-author links

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2 shared papersCancer Biology

John G. DoenchORCID

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2 papers

Recent·Most cited

Cancer BiologyJournal of Thoracic OncologyPeer-reviewedAug 1, 2025

Cyclin A/B RxL Macrocyclic Inhibitors to Treat Cancers with High E2F Activity

Shilpa Singh, Catherine E. Gleason, Min Fang…·Matthew G. Oser

This paper develops cyclin A/B macrocyclic inhibitors that induce apoptosis in cancers with high E2F activity by blocking RxL-mediated interactions, showing efficacy in SCLC models.

29 citationstop 1%

humanproteomics

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Cancer BiologyCancer CellPeer-reviewedJul 18, 2024

Mammalian SWI/SNF complex activity regulates POU2F3 and constitutes a targetable dependency in small cell lung cancer

Leslie Duplaquet, Kevin So, Alexander Wang Ying…·Matthew G. Oser

This study identifies mSWI/SNF complex activity as a targetable dependency in POU2F3-positive small cell lung cancer, showing that inhibiting mSWI/SNF or BRD9 reduces tumor growth and improves survival.

75 citationstop 1%

humanbulk RNA-seq

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