Inhibition of PIM kinase in tumor associated macrophages suppresses inflammasome 1 activation and sensitizes prostate cancer to immunotherapy
Amber N. Clements, Andrea L. Casillas, Caitlyn E. Flores, Hope Liou, Rachel K. Toth, Shailender Singh Chauhan, Kai Sutterby, Sachin Kumar Deshmukh, Sharon Wu, Joanne Xiu, Alex Patrick Farrell, Milan Radovich, Chadi Nabhan, Elisabeth I. Heath, Rana R. McKay, , Noel A. Warfel
This study shows that inhibiting PIM kinases in tumor-associated macrophages reduces inflammasome activation and improves response to immunotherapy in prostate cancer.
Cancer Immunology Research · Feb 21, 2025Peer-reviewedCancer Biology