Author

Sebastiaan L. Tetteroo

ORCID 0009-0002-0609-1962Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Biochemistry· 1

Signature Assays, Organisms & Methods

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Research Focus:drug response / drug discovery· 1 Assay:protein structure· 1 Approach:statistical model· 1

Frequent Co-Authors

Chelsea Tawiah· 1 shared Gillian DekkersiD· 1 shared Matti F. PronkeriD· 1 shared

Activity by Year

2026-2026 · peak 1/yr

Co-Author Collaboration Network

3 top collaborators · 3 mutual co-author links

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1 shared paperBiochemistry

Chelsea Tawiah

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1 paper

Recent·Most cited

BiochemistrybioRxivPreprintOct 14, 2026

Affinity maturation of a single-domain antibody via rational mutagenesis informed by artificial intelligence

Sebastiaan L. Tetteroo, Chelsea Tawiah, Gillian Dekkers, Matti F. Pronker

The paper uses AI-predicted protein structures to guide rational mutagenesis of a single-domain antibody, enhancing its binding affinity to IL-12 by eightfold.

DOI 10.64898/2026.10.13.758789

protein structurestatistical model

𝕏 PostBluesky