Matti F. Pronker

The paper uses AI-predicted protein structures to guide rational mutagenesis of a single-domain antibody, enhancing its binding affinity to IL-12 by eightfold.

This study determines the epitope of the postfusion-specific antibody 131-2a against RSV-F using mass spectrometry, revealing the structural basis for its specificity.

The paper determines the atomic structure of the FLAG peptide bound to anti-FLAG M2 Fab, identifies key interactions, and proposes a shorter FLAG-tag variant with equivalent binding.