Author

Gillian Dekkers

ORCID 0000-0002-9127-356XUnclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Organism:human· 2 Assay:protein structure· 2 Research Focus:drug response / drug discovery· 1 Research Focus:host-pathogen & immune response· 1 Research Focus:protein folding & dynamics· 1 Assay:proteomics· 1 Approach:statistical model· 1

Frequent Co-Authors

Raimond HeukersiD· 2 shared Alexander FishiD· 1 shared Alsya J. AffandiiD· 1 shared Angeliki MoutsiopoulouiD· 1 shared Astrid P. HeikemaiD· 1 shared Bart W. BardoeliD· 1 shared Chelsea Tawiah· 1 shared D.A.M. Heijnen· 1 shared

Activity by Year

2025-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

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2 shared papersImmunology

Raimond HeukersORCID

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3 papers

Recent·Most cited

BiochemistrybioRxivPreprintOct 14, 2026

Affinity maturation of a single-domain antibody via rational mutagenesis informed by artificial intelligence

Sebastiaan L. Tetteroo, Chelsea Tawiah, Gillian Dekkers, Matti F. Pronker

The paper uses AI-predicted protein structures to guide rational mutagenesis of a single-domain antibody, enhancing its binding affinity to IL-12 by eightfold.

DOI 10.64898/2026.10.13.758789

protein structurestatistical model

ImmunologybioRxivPreprintSep 3, 2026

Identification of a C3b-specific nanobody that does not bind C3 and blocks alternative pathway convertases

Eva M. Struijf, Bart W. Bardoel, Joanne E. van Keulen…·Jamie S. Depelteau

This study identifies a C3b-specific nanobody that binds C3b but not C3, and inhibits the alternative pathway convertases of the complement system.

DOI 10.64898/2026.08.30.748118

humanprotein structure

ImmunologybioRxivPreprintDec 22, 2025

Identification of allo- or orthosteric VHH/single-domain antibodies that enhance or block pathogen binding to Siglec-1 on dendritic cells

Hendrik J. Brink, Alsya J. Affandi, Sandra Man-Bovenkerk…·Joke M. M. den Haan

The paper identifies VHH/single-domain antibodies that either block or enhance Siglec-1 ligand binding to sialylated pathogens on dendritic cells.

1 citation

humanproteomics