Xi Peng

This study knocks out the DPYSL2-B isoform in human iPSC-derived neurons, showing reduced dendrite length and transcriptomic changes linked to mTOR signaling and schizophrenia.

The paper performs mediation analysis on schizophrenia-associated variants using brain gene expression datasets to determine how eQTL target genes mediate risk, finding that expression effects often have unexpected directions.

The paper investigates the transcriptomic response of induced excitatory neurons to Clozapine, finding significant upregulation of cholesterol metabolism genes.