Author

Debamitra Das

Johns Hopkins UniversityORCID 0000-0002-9207-6912Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Organism:human· 5 Approach:experimental assay· 4 Research Focus:differential expression· 2 Research Focus:drug response / drug discovery· 2 Organism:mouse· 2 Assay:scRNA-seq· 2 Approach:statistical model· 2 Assay:ATAC-seq· 1

Frequent Co-Authors

Brady J. MaheriD· 4 shared Srinidhi Rao SripathyiD· 4 shared Gina ShimiD· 3 shared Dimitrios AvramopoulosiD· 2 shared Federica FarinelliiD· 2 shared Isaac OstlundiD· 2 shared Joseph F. BohleniD· 2 shared Rakaia F. Kenney· 2 shared

Activity by Year

2020-2025 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 26 mutual co-author links

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4 shared papersNeuroscience

Brady J. MaherORCID

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Author profile →

7 papers

Recent·Most cited

Automated high-throughput patch clamp electrophysiology of hiPSC-derived neuronal models

Federica Farinelli, Isaac Ostlund, Srinidhi Rao Sripathy, Debamitra Das, Gina Shim, Sangho Myung, Richard E. Straub, Brady J. Maher

This paper introduces automated high-throughput patch clamp electrophysiology methods for hiPSC-derived neurons, enabling efficient analysis of voltage-gated sodium channels and pharmacological responses.

bioRxiv · May 12, 2025 · PreprintNeuroscience

TCF4 mutations disrupt synaptic function through dysregulation of RIMBP2 in patient-derived cortical neurons

Brittany A. Davis, Huei-Ying Chen, Zengyou Ye, Isaac Ostlund, Madhavi Tippani, Debamitra Das, Srinidhi Rao Sripathy, Yanhong Wang, Jacqueline M. Martín, Gina Shim, Neel M. Panchwagh, Rebecca L. Moses, Federica Farinelli, Joseph F. Bohlen, Meijie Li, , Brady J. Maher

This study shows TCF4 mutations impair synaptic function in patient-derived cortical neurons by disrupting RIMBP2 expression, leading to deficits in synaptic transmission and network excitability.

Biological Psychiatry · Apr 1, 2024Peer-reviewedNeuroscience

Evaluation of Nav1.8 as a therapeutic target for Pitt Hopkins Syndrome

Keri Martinowich, Debamitra Das, Srinidhi Rao Sripathy, Yishan Mai, Rakaia F. Kenney, Brady J. Maher

The paper evaluates Nav1.8 as a therapeutic target for Pitt Hopkins Syndrome by reviewing literature and presenting data showing its inhibition normalizes neuron function and behavior in mouse models.

Molecular Psychiatry · Oct 12, 2022Peer-reviewedNeuroscience

Clemastine fumarate enhances myelination and promotes functional recovery in a syndromic ASD mouse model of Pitt-Hopkins Syndrome

Joseph F. Bohlen, Colin M. Cleary, Debamitra Das, Srinidhi Rao Sripathy, Norah Sadowski, Gina Shim, Rakaia F. Kenney, Ingrid P. Buchler, Daniel Kent Mulkey, Brady J. Maher

bioRxiv · May 3, 2022 · PreprintNeuroscience

Transcriptome Analysis of Human Induced Excitatory Neurons Supports a Strong Effect of Clozapine on Cholesterol Biosynthesis

Debamitra Das, Xi Peng, Anh-Thu N. Lam, Joel S. Bader, Dimitrios Avramopoulos

The paper investigates the transcriptomic response of induced excitatory neurons to Clozapine, finding significant upregulation of cholesterol metabolism genes.

Schizophrenia Research · Jan 23, 2021Peer-reviewedNeuroscience

Astrocyte- and neuron-derived extracellular vesicles from Alzheimer's disease patients effect complement-mediated neurotoxicity

Carlos J. Nogueras‐Ortiz, Vasiliki Mahairaki, Francheska Delgado‐Peraza, Debamitra Das, Konstantinos Ioannis Avgerinos, Erden Eren, Matthew B Hentschel, Edward J. Goetzl, Mark P. Mattson, Dimitrios Kapogiannis

The paper tests whether Alzheimer's disease patient-derived extracellular vesicles induce complement-mediated neurotoxicity in neurons.

Cells · Jul 4, 2020Peer-reviewedNeuroscience

Publicly available hiPSC lines with extreme polygenic risk scores for modeling schizophrenia

Kristina Dobrindt, Hanwen Zhang, Debamitra Das, Sara Abdollahi, Tim Prorok, Sulagna Dia Ghosh, Sarah J. Weintraub, Giulio Genovese, Samuel K. Powell, Anina N. Lund, Schahram Akbarian, Kevin C. Eggan, Steven A. McCarroll, Jubao Duan, Dimitrios Avramopoulos, Kristen Brennand

The paper presents twelve hiPSC lines with extreme polygenic risk scores for schizophrenia, available for CRISPR-based functional studies.

Complex Psychiatry · Jan 1, 2020Peer-reviewedGenomics