Andrew B. Tobin

This paper reports the cryo-EM structure of the M4 mAChR bound to MK-97 and acetylcholine, revealing how MK-97's binding mode improves PAM activity through distributed interactions.

This study shows that M1 receptor phosphorylation is critical for contextual memory but not cued memory, and biased Gq signaling alone is insufficient for restoring contextual memory.

This paper introduces a real-time fluorescence lifetime imaging method using single-snapshot acquisitions, demonstrating its application in biomedical scenarios from microscopic to macroscale.

This study shows that inhibiting PfCLK3 disrupts RNA-splicing in malaria parasites, affecting 1125 genes and providing a novel mechanism for a radical cure.

The paper identifies a subpopulation of M4 mAChR-expressing astrocytes that regulate locomotion and have a detrimental effect in murine prion disease.

This study shows that activating M1 muscarinic receptors with VU846 slows murine prion disease progression, reduces neuroinflammation, and preserves synaptic proteins.

This study identifies PfCLK3 as a druggable target for malaria by showing its essential role in multiple parasite life stages across species.