涵宇 蒋

This study shows that timing of TGF-β blockade and material context affect matrix retention in bioprinted keratoconus stroma, with optimal regimens improving collagen retention and reducing contractile gene expression.

The paper examines failed allogeneic corneal lenticules, finding fibrosis and loss of corneal identity without dominant T cell rejection, and explores treatment strategies.

corrdeconv corrects deconvolution errors by addressing misread disease cell states as abundance, outperforming existing methods and reducing refuted effects.

ResponseVerdict improves immune checkpoint blockade response prediction by outperforming existing signatures and predictors using data from prior studies.

TRUEDA identifies true pathogens in low-biomass disease-microbe associations by accounting for contamination, outperforming existing decontamination methods and correcting false associations.

This paper reinterprets keratoconus gene expression by showing that expression direction depends on control choice and stromal state, not disease causation or intervention effectiveness.

With an incomplete deconvolution reference, operator history changes estimates and associations, and the target is not point-identified; fitdrop scores remedies on shrinkage, coverage, certification and false certification, and prices measurements.