Ying Li

Material context and TGF-β blockade timing determine retained matrix in patient-derived bioprinted keratoconus stroma

This study shows that timing of TGF-β blockade and material context affect matrix retention in bioprinted keratoconus stroma, with optimal regimens improving collagen retention and reducing contractile gene expression.

Failed allogeneic corneal lenticules show fibrosis and identity loss without dominant T cell rejection

The paper examines failed allogeneic corneal lenticules, finding fibrosis and loss of corneal identity without dominant T cell rejection, and explores treatment strategies.

corrdeconv corrects deconvolution's misreading of disease cell states as abundance, overturning benchmarks and outperforming every published deconvolution method

corrdeconv corrects deconvolution errors by addressing misread disease cell states as abundance, outperforming existing methods and reducing refuted effects.

ResponseVerdict overturns computationally validated immunotherapy signatures, recovers their missed responders and outperforms every published response predictor

ResponseVerdict improves immune checkpoint blockade response prediction by outperforming existing signatures and predictors using data from prior studies.

TRUEDA overturns replicated, decontaminated low-biomass disease-microbe associations and clinical decisions, recovers true pathogens and outperforms every decontamination method

TRUEDA identifies true pathogens in low-biomass disease-microbe associations by accounting for contamination, outperforming existing decontamination methods and correcting false associations.

Reinterpreting Keratoconus Gene Expression in Light of Inherited Stromal Weakness

This paper reinterprets keratoconus gene expression by showing that expression direction depends on control choice and stromal state, not disease causation or intervention effectiveness.

Incomplete references leave bulk deconvolution targets non-identifiable, but identification has a computable precision price

With an incomplete deconvolution reference, operator history changes estimates and associations, and the target is not point-identified; fitdrop scores remedies on shrinkage, coverage, certification and false certification, and prices measurements.

Post-weaning social isolation impairs the orbitofrontal cortical circuit subserving contagious pain and prosocial behaviors

This study shows that post-weaning social isolation impairs empathic behaviors in mice by disrupting glutamatergic signaling in the orbitofrontal cortex.

Decoding the Valence of Developmental Social Behavior: Dopamine Governs Social Motivation Deficits in Autism

This study identifies NAc dopamine as a dynamic encoder of social valence and shows that modulating dopaminergic circuits can rescue social deficits in ASD models.

Distinct cellular mediators drive the Janus Faces of Toll-like Receptor 4 regulation of network excitability which impacts working memory performance after brain Injury

This paper identifies distinct cellular mechanisms by which TLR4 regulates network excitability and working memory after brain injury, showing TNF's role in mediating these effects.