Yang Jiang

Material context and TGF-β blockade timing determine retained matrix in patient-derived bioprinted keratoconus stroma

This study shows that timing of TGF-β blockade and material context affect matrix retention in bioprinted keratoconus stroma, with optimal regimens improving collagen retention and reducing contractile gene expression.

Failed allogeneic corneal lenticules show fibrosis and identity loss without dominant T cell rejection

The paper examines failed allogeneic corneal lenticules, finding fibrosis and loss of corneal identity without dominant T cell rejection, and explores treatment strategies.

corrdeconv corrects deconvolution's misreading of disease cell states as abundance, overturning benchmarks and outperforming every published deconvolution method

corrdeconv corrects deconvolution errors by addressing misread disease cell states as abundance, outperforming existing methods and reducing refuted effects.

ResponseVerdict overturns computationally validated immunotherapy signatures, recovers their missed responders and outperforms every published response predictor

ResponseVerdict improves immune checkpoint blockade response prediction by outperforming existing signatures and predictors using data from prior studies.

TRUEDA overturns replicated, decontaminated low-biomass disease-microbe associations and clinical decisions, recovers true pathogens and outperforms every decontamination method

TRUEDA identifies true pathogens in low-biomass disease-microbe associations by accounting for contamination, outperforming existing decontamination methods and correcting false associations.

DiffRhyShiny: A Benchmarking-Informed Platform for Differential Rhythmicity Analysis with Dependence-Aware Evidence Integration

The paper benchmarks differential rhythmicity analysis methods and introduces a web platform for robust analysis and visualization of rhythmicity changes.

Matrix-Mechanical Genetic Susceptibility and Reduced Inflammatory and Immediate-Early Programs in Keratoconus

This study identifies genetic susceptibility in keratoconus linked to extracellular matrix mechanisms and shows reduced inflammatory and immediate-early gene expression in corneal tissue.

Incomplete references leave bulk deconvolution targets non-identifiable, but identification has a computable precision price

With an incomplete deconvolution reference, operator history changes estimates and associations, and the target is not point-identified; fitdrop scores remedies on shrinkage, coverage, certification and false certification, and prices measurements.

A Priming Circuit Controls the Olfactory Response and Memory in Drosophila

This study identifies a priming circuit in Drosophila that modulates olfactory response and memory based on prior aversive or appetitive stimuli.