Accelerated osteocytic citrate production in chronic kidney disease is associated with protection of the kidney
Jie Ren Gerald Har, Maggie Yun-Hsuan Hsu, Keith Louis Saum, Akshdeep Singh, R. Sriram, Dylan P. Kuennen, Emily K Zhu, Subramaniam Pennathur, Maciek R. Antoniewicz, Lauren E. Surface
This study shows that accelerated citrate production by osteocytes in CKD mice protects kidney function, suggesting citrate handling as a therapeutic target.
Journal of Bone and Mineral Research · Jul 23, 2026Peer-reviewedPhysiology