Cross-species neural co-culture uncovers metabolic signatures of cellular crosstalk
Katherine Rickelton, Rithvik Sandiri, Jessica Roy, Aliyah Dalier, Courtney C. Babbitt
The paper develops a cross-species co-culture model of astrocytes and neurons from human and chimpanzee iPSCs to study metabolic differences and finds human co-cultures are more metabolically active, with astrocytes driving species-specific metabolic differences.
bioRxiv · Aug 1, 2026 · PreprintEvolutionary Biology