Courtney C. Babbitt

The paper develops a cross-species co-culture model of astrocytes and neurons from human and chimpanzee iPSCs to study metabolic differences and finds human co-cultures are more metabolically active, with astrocytes driving species-specific metabolic differences.

The paper analyzes bulk RNA-seq data from six primate cerebellar subregions to identify gene expression differences across species, highlighting divergence in synaptic activity and glucose metabolism in lateral hemispheres.