Author

Shipeng Xu

University of California, DavisORCID 0009-0002-2895-8635Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Organism:human· 2 Approach:biophysical modeling· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:drug response / drug discovery· 1 Approach:microscopy & imaging analysis· 1 Assay:protein structure· 1 Assay:proteomics· 1

Frequent Co-Authors

Sanjeevi SivasankariD· 2 shared Bin XieiD· 1 shared Nishadi H Mudiyanselage· 1 shared

Activity by Year

2025-2025 · peak 2/yr

Co-Author Collaboration Network

3 top collaborators · 2 mutual co-author links

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2 shared papersBiophysics

Sanjeevi SivasankarORCID

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2 papers

Recent·Most cited

P-cadherin and desmoglein-2 interact as strand-swap dimers and facilitate desmosome assembly.

Shipeng Xu, Nishadi H Mudiyanselage, Sanjeevi Sivasankar

This study identifies how P-cadherin and Desmoglein-2 form strand-swap dimers to facilitate desmosome assembly through structural and functional analyses.

bioRxiv · Sep 15, 2025 · PreprintBiophysics

Outside-in engineering of cadherin endocytosis using a conformation strengthening antibody.

Bin Xie, Shipeng Xu, Sanjeevi Sivasankar

This study shows that an antibody can trigger cadherin endocytosis by stabilizing an X-dimer conformation, leading to lysosomal targeting and providing a mechanism for intracellular drug delivery.

Nature Communications · Jan 29, 2025Peer-reviewedBiophysics