Sanjeevi Sivasankar

This study develops a DAT proximity labeling system to characterize cadherin cis interactions in live cells, revealing both specific and non-specific dimerization modes and their effects on junctional stability.

The paper shows actomyosin forces cause desmoplakin to change conformation in desmosomes, revealing its mechanosensitivity.

This study identifies how P-cadherin and Desmoglein-2 form strand-swap dimers to facilitate desmosome assembly through structural and functional analyses.

This study shows that an antibody can trigger cadherin endocytosis by stabilizing an X-dimer conformation, leading to lysosomal targeting and providing a mechanism for intracellular drug delivery.