A Mimicry-Based Strategy Between Human and Commensal Antigens for the Development of a New Family of Immune Therapies for Cancer
Alice Talpin, Ana Rita R. Maia, Jean-Marie Carpier, Guillaume Kulakowski, Lucie Aubergeon, Jérôme Kervevan, Camille Gaal, Francesco Strozzi, Coline Billerey, Ludivine Amable, Tifanny Mersceman, Alexandrine Garnier, Catia Pereira Oliveira, Carolina Calderon, Diana Bachrouche, , Joao Gamelas Magalhaes
This paper introduces OncoMimics, a peptide-based immunotherapy using molecular mimicry between commensal bacterial and tumor antigens to induce cross-reactive T cell responses, showing early clinical success in glioblastoma.
Journal for ImmunoTherapy of Cancer · Feb 1, 2025Peer-reviewedImmunology