Disruption of CaMKII biomolecular condensation induces attention-deficit/hyperactivity disorder-like phenotypes
Yui Sugiyama, Chisato Suematsu, Risa Yamada, Atsuki Goda, Shogo Miyata, Tokiwa Yamasaki, Ryuichi Shigemoto, Anjuli Dijkmans, Danielle C. M. Veenma, Shoji Takada, Geeske M. van Woerden, Yasunori Hayashi, Takeo Saneyoshi
This study shows that disrupting CaMKII's liquid-liquid phase separation with synaptic partners causes ADHD-like behaviors and memory deficits in mice, mirroring a human patient with a similar mutation.
bioRxiv · Jun 29, 2026 · PreprintNeuroscience