Geeske M. van Woerden

This study shows that disrupting CaMKII's liquid-liquid phase separation with synaptic partners causes ADHD-like behaviors and memory deficits in mice, mirroring a human patient with a similar mutation.

This study shows that Purkinje cell intrinsic activity before synaptic maturation is critical for dendrite growth, connectivity, and cerebellar function, with early disruptions causing severe morphological and functional defects.

The paper identifies PSMC5 variants causing neurodevelopmental disorders and shows their impact on neuronal function and immune signaling, suggesting therapeutic targets.

autoMEA is a machine learning tool for automated burst detection in multi-electrode array data, showing accuracy comparable to manual analysis in detecting network dynamics.

The paper identifies novel endogenous CAMK2 substrates by analyzing phosphoproteomic data from double knockout mice.

This study models mTORopathy-related epilepsy in cultured murine hippocampal neurons using a multi-electrode array to identify network activity phenotypes and test drug treatments.

This study shows TMX2 is essential for newborn neuron survival during zebrafish embryonic brain development, with loss causing rapid cell death and calcium dysregulation.

This study shows that restoring CAMK2A expression in adult Camk2a knockout mice rescues learning and plasticity deficits, indicating that CAMK2A is not essential for irreversible neurodevelopment.

This study shows that loss of both CAMK2A and CAMK2B causes bidirectional changes in neuronal excitability and synaptic transmission in hippocampal CA1 pyramidal neurons.

This study shows that RHEB/mTOR hyperactivity causes cortical malformations and seizures through increased axonal connectivity, not just local malformations.