Yasunori Hayashi

This study identifies distinct roles of prefrontal plasticity in controlling decision-making strategy and habit execution in male mice.

This study shows that disrupting CaMKII's liquid-liquid phase separation with synaptic partners causes ADHD-like behaviors and memory deficits in mice, mirroring a human patient with a similar mutation.

This study identifies a top-down pathway from the anterior cingulate cortex to the retrosplenial cortex that encodes reward-context associations and shapes hippocampal saliency maps.

The paper develops a computational model of CaMKII phase separation that identifies structural features enabling multiphase condensates and their functional relevance to synaptic memory.

The paper identifies DRACC1 as a novel synaptic protein that facilitates PSD protein assembly through liquid-liquid phase separation by analyzing 35 PSD proteome datasets.

The paper introduces an improved CNMF-based algorithm for calcium imaging data analysis, enhancing cell detection accuracy and signal quality.

The paper identifies sublayer- and cell-type-specific transcriptional changes in hippocampal sclerosis using single-nucleus and bulk RNA sequencing, revealing distinct neurodegenerative trajectories in superficial CA1 neurons.

The paper shows that CaMKII activation leads to persistent liquid-liquid phase separation with GluN2B, forming stable postsynaptic assemblies that enhance synaptic transmission and memory formation.

This study shows that hippocampal ripple-mediated replay transforms fragmented spatial codes into stable cortical contextual representations through experience-dependent synaptic remodeling.

The paper introduces a wearable neuroimager for whole-brain imaging in mice, revealing premotor activity across the motor cortex.

The paper investigates how hippocampal CA1 neurons dynamically represent and stabilize spatial maps in mice learning a virtual-reality navigation task, showing that salient experiences like rewards reshape these maps through selective consolidation.

The paper improves cell activity estimation in calcium imaging data using non-negative matrix decomposition with shrinkage estimation and enhanced initialization methods.