Ryuichi Shigemoto

This study examines nanoscale changes in synaptic proteins in human temporal lobe epilepsy, finding increased AMPA receptor density and altered calcium channel organization in specific synapse types.

This study shows that physiological learning in mice leads to intrasynaptic reorganization of GluA1-containing AMPA receptors at CA1 synapses, with increased density and clustering of GluA1 and reduced GluA2.

This study shows that the left medial habenula (MHb) in mice has functional asymmetry in fear expression, mediated by GABAB receptors, and this asymmetry is influenced by internal organ laterality.

The paper demonstrates that baseline-normalized metrics are essential for accurately interpreting fear memory in mice, showing that conventional freezing scores confound locomotor activity.

This study shows that disrupting CaMKII's liquid-liquid phase separation with synaptic partners causes ADHD-like behaviors and memory deficits in mice, mirroring a human patient with a similar mutation.

The paper demonstrates that presynaptic cAMP-PKA-mediated potentiation increases synaptic vesicle pool size and channel-vesicle coupling at hippocampal mossy fiber boutons.

This study investigates how LGI1 autoantibodies enhance synaptic transmission by reducing Kv1 channel density and broadening presynaptic action potentials.

This study identifies multipotent progenitors in the superior colliculus that generate all excitatory and inhibitory neuron types without extrinsic input.

This study quantifies the nanoscale distribution of PI(4,5)P2 on mouse cerebellar neuron membranes and shows its clustering with specific proteins in different compartments.

The paper identifies a two-pool mechanism in medial habenula terminals where GABAB receptor activation increases the readily releasable pool and alters vesicle coupling distances.

The paper identifies a shared visual perception and place avoidance deficit in ASD models, linked to Kv1 channel hypoexcitability in the dPAG, and shows pharmacological rescue of these deficits.

The paper investigates how synaptic integration matures in cerebellar interneurons, finding that changes in synapse distribution, not dendritic properties, drive the development of a two-stage integration model.

This paper investigates the role of RIM-BP2 in organizing Ca2+ channel topography and regulating synaptic vesicle release probability and replenishment at a fast central synapse.

The paper investigates how GABAB receptor auxiliary subunits modulate Cav2.3-mediated neurotransmitter release in medial habenula terminals, revealing their role in synaptic strength regulation.

This study shows that presynaptic α2δ subunits are essential for glutamatergic synapse formation and organization, acting as trans-synaptic organizers.

This study compares synaptic function in mouse cerebellar slices prepared at ice-cold and physiological temperatures, finding that physiological temperature preserves synaptic structure and function better.

This study shows HCN channels modulate action potential velocity and fidelity in central axons through cAMP and neuromodulators, with implications for energy consumption and temporal delays.

This study identifies a ventral hippocampal pathway that gates novelty-driven memory formation by activating dorsal hippocampal granule cells.