Charles C. Query

Productive mRNA Chromatin Escape is Promoted by PRMT5 Methylation of SNRPB

The paper shows PRMT5 promotes chromatin escape of mRNAs by methylating SNRPB, affecting splicing and nuclear export.

PRMT5 activity sustains histone production to maintain genome integrity

This study shows PRMT5 sustains histone transcription and protein synthesis during S phase, maintaining genome integrity by regulating histone H4 methylation.

U2-2 snRNA Mutations Alter the Transcriptome

The paper studies how mutations in U2 snRNA affect splicing and gene expression, finding that U2-2 knockout phenocopies mutant effects and that splicing changes are influenced by both mutation and U2-2 levels.

Spatial organization of transcript elongation and splicing kinetics

This study measures Pol II elongation and splicing kinetics genome-wide and finds they are coordinated by spatial genomic organization, particularly within TADs.

Transcriptional analysis supports the expression of human snRNA variants and reveals U2 snRNA homeostasis by an abundant U2 variant

The paper identifies transcribed snRNA variants and shows how sequence variation and promoter regulation affect U2 snRNA homeostasis and splicing.