Varun Gupta

The paper shows PRMT5 promotes chromatin escape of mRNAs by methylating SNRPB, affecting splicing and nuclear export.

This study shows PRMT5 sustains histone transcription and protein synthesis during S phase, maintaining genome integrity by regulating histone H4 methylation.

The paper studies how mutations in U2 snRNA affect splicing and gene expression, finding that U2-2 knockout phenocopies mutant effects and that splicing changes are influenced by both mutation and U2-2 levels.

The paper investigates the substrate preferences and functional consequences of Type I and II PRMTs by inhibiting them in A549 cells and analyzing proteomic and transcriptomic changes.

The paper identifies transcribed snRNA variants and shows how sequence variation and promoter regulation affect U2 snRNA homeostasis and splicing.