Translational Opportunity of Engineered IFNγ-eEVs Through Targeted Inhibition of JAK/STAT1 Signaling, Mimicking IVIg Therapy
Kylie E Preihs, Kübra Karagoz, Claire R Shuey, Amritha Achuthkumar, Ana M Pivovarnik, Sophia M. Crocker, Michelle L. Pleet, Jubin George, Robert D. Carlson, Adam Eugene Snook, Adam Luginbuhl, Peter J. Wermuth, Andreas Möller, Jennifer Clare Jones, Larry A. Harshyne, , My G Mahoney
This paper identifies EV-associated cytokines as mediators of IVIg activity, showing that engineered IFNγ-eEVs can suppress IFNγ signaling through context-dependent mechanisms.
bioRxiv · May 3, 2026 · PreprintBioengineering