NeuroscienceMolecular Therapy — Nucleic AcidsPeer-reviewed
Systemic and Local Delivery of siRNA to the CNS and Periphery via Anti-IGF1R Antibody Conjugation
Mengnan Tian, Mehran Nikan, Miran Yoo…·Sungwon An
This study develops an siRNA-antibody conjugate targeting IGF1R for systemic and CNS delivery, showing effective knockdown in multiple tissues and good tolerability.
DOI 10.1016/j.omtn.2026.103105