Author

Mengnan Tian

Ionis Pharmaceuticals (United States)ORCID 0000-0002-5011-2719Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Neuroscience· 3

Signature Assays, Organisms & Methods

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Assay:bulk RNA-seq· 2 Approach:experimental assay· 2 Organism:human· 2 Research Focus:cell-cell communication· 1 Research Focus:differential expression· 1 Research Focus:gene regulatory network inference· 1 Research Focus:GWAS / association mapping· 1 Organism:mouse· 1

Frequent Co-Authors

Richard L. HuganiriD· 2 shared Akira SawaiD· 1 shared Asa Wahlander· 1 shared Atsushi SaitoiD· 1 shared Austin R. GravesiD· 1 shared Brian J. LeeiD· 1 shared Byeong Min YooiD· 1 shared Daisuke Fukudome· 1 shared

Activity by Year

2021-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 16 mutual co-author links

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2 shared papersNeuroscience

Richard L. HuganirORCID

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3 papers

Recent·Most cited

NeuroscienceMolecular Therapy — Nucleic AcidsPeer-reviewedSep 18, 2026

Systemic and Local Delivery of siRNA to the CNS and Periphery via Anti-IGF1R Antibody Conjugation

Mengnan Tian, Mehran Nikan, Miran Yoo…·Sungwon An

This study develops an siRNA-antibody conjugate targeting IGF1R for systemic and CNS delivery, showing effective knockdown in multiple tissues and good tolerability.

DOI 10.1016/j.omtn.2026.103105

experimental assay

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NeuroscienceNeuronPeer-reviewedNov 14, 2022

The miR-124-AMPAR pathway connects polygenic risks with behavioral changes shared between schizophrenia and bipolar disorder

Ho Namkung, Hiroshi Yukitake, Daisuke Fukudome…·Akira Sawa

This study identifies the miR-124-AMPAR pathway as a common mediator linking polygenic risks to shared behavioral changes in schizophrenia and bipolar disorder.

50 citationstop 2%

humanbulk RNA-seq

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NeurosciencebioRxivPreprintOct 26, 2021

KIBRA-PKCγ signaling pathway modulates memory performance in mice and humans

Mengnan Tian, Qiang Chen, Austin R. Graves…·Richard L. Huganir

This study identifies the KIBRA-PKCγ signaling pathway as crucial for modulating memory performance in both mice and humans.

5 citations

humanmouse

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