Systemic and Local Delivery of siRNA to the CNS and Periphery via Anti-IGF1R Antibody Conjugation
Mengnan Tian, Mehran Nikan, Miran Yoo, Stephanie K. Klein, Seung‐Hwan Kwon, John E. Matson, Dongin Kim, Jinwon Jung, Sumin Hyeon, Byeong Min Yoo, Hyeon Ji Park, Michael Tanowitz, Asa Wahlander, Weon‐Kyoo You, Hakju Kwon, , Sungwon An
This study develops an siRNA-antibody conjugate targeting IGF1R for systemic and CNS delivery, showing effective knockdown in multiple tissues and good tolerability.
Molecular Therapy — Nucleic Acids · Sep 18, 2026Peer-reviewedNeuroscience