Mehran Nikan

This study develops an siRNA-antibody conjugate targeting IGF1R for systemic and CNS delivery, showing effective knockdown in multiple tissues and good tolerability.

The paper shows that endolysosomal damage leads to intraluminal protein condensates that prevent cytosolic leakage and sequester therapeutic oligonucleotides.

The paper introduces an automated AI pipeline for correlating chemical and ultrastructural images to enable organelle-specific molecular imaging in cells and tissues.

This paper introduces modified nucleosides in siRNA seed regions to enhance specificity and reduce off-target effects while maintaining on-target activity.

The paper shows that inhibiting the CPEB3 ribozyme increases CPEB3 protein and enhances memory by promoting mRNA polyadenylation and translation.

The paper shows that the CPEB3 ribozyme regulates hippocampal-dependent memory by modulating mRNA maturation and translation of plasticity-related genes.