Mitochondrial turnover at central GABAergic synapses governs vulnerability to epileptic seizures
Kristiano Ndoci, Abdulla W. Chihab, Kiruthika Ganesan, Milica Jevtic, Kelvin Maximilian Tofan, Gulzar A. Wani, Patric Pelzer, Jorge A. Soriano-Campos, Franka Odenthal, Vignesh Sakthivelu, Camilla Aurora Franchino, Laura Pérez-Revuelta, Jonas Benz, Anna‐Lena Schumacher, Felix Gaedke, , Matteo Bergami
This study shows that mitochondrial turnover at GABAergic synapses affects seizure vulnerability, with gene therapy reversing the effects.
bioRxiv · Jun 28, 2026 · PreprintNeuroscience