Vignesh Sakthivelu

This study benchmarks preprocessing strategies for single-cell transformer models and finds that simple log-transformed counts outperform complex methods, leading to a more efficient foundation model.

This study shows that mitochondrial turnover at GABAergic synapses affects seizure vulnerability, with gene therapy reversing the effects.

This study identifies NMD inhibition as a therapeutic strategy for SCLC by enhancing immunogenicity and improving immunotherapy efficacy through increased neoantigen presentation.

This study identifies YME1L as a mitochondrial protease that regulates metabolic state transitions in adult neural stem cells, ensuring self-renewal and preventing premature differentiation.