Author

Georgios Kyriakakis

University of CopenhagenORCID 0009-0002-4590-0259Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Assay:bulk RNA-seq· 1 Research Focus:cell-cell communication· 1 Approach:deep learning· 1 Research Focus:drug response / drug discovery· 1 Assay:fluorescence / live-cell microscopy· 1 Organism:human· 1 Approach:microscopy & imaging analysis· 1

Frequent Co-Authors

Artù BreueriD· 2 shared Frank SchulziD· 2 shared Georgios BolisiD· 2 shared Nikos S. HatzakisiD· 2 shared Athanasios OikonomouiD· 1 shared Emily Winther SørenseniD· 1 shared Guangjun NieiD· 1 shared Jacob Kæstel‐HanseniD· 1 shared

Activity by Year

2026-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 40 mutual co-author links

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2 shared papersBiophysics

Artù BreuerORCID

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2 papers

Recent·Most cited

Tuning siRNA packing order in lipid nanoparticles modulates oligonucleotide functional delivery

Artù Breuer, Georgios Kyriakakis, Marcus Winther Dreisler, Frank Schulz, Georgios Bolis, Stavroula Margaritaki, Vasilis Papageorgiou, Ntaniela Spacho, Nikos S Hatzakis

This study shows that tuning siRNA packing order in lipid nanoparticles improves functional delivery by enhancing silencing potency through less compact packing.

bioRxiv · May 22, 2026 · PreprintBiophysics

Rapid and reliable quantification of cytosolic mRNA escape (RNASCAPE)

Frank Schulz, Emily Winther Sørensen, Steen W.B. Bender, Artù Breuer, Georgios Kyriakakis, Jacob Kæstel‐Hansen, Georgios Bolis, Athanasios Oikonomou, Konstantinos Tsolakidis, Stefanos Arampatzis, Guangjun Nie, Nikos S. Hatzakis

RNASCAPE quantifies mRNA cytosolic escape using deep learning, achieving 78% accuracy with three timepoints and LNP parameters, revealing cholesterol's impact on mRNA release.

bioRxiv · Apr 11, 2026 · PreprintBiophysics