Athanasios Oikonomou

CRISPR-VUS identifies rare variants linked to gene dependency in cancer cell lines, prioritizing potential drivers and therapeutic targets through functional validation.

This paper develops GepiClock, an epigenetic clock for cancer cells, revealing age-related therapeutic vulnerabilities in cancer cell lines.

BioBrain translates natural language into reproducible microscopy analysis pipelines, outperforming language models in accuracy while enabling non-experts to analyze complex imaging data.

RNASCAPE quantifies mRNA cytosolic escape using deep learning, achieving 78% accuracy with three timepoints and LNP parameters, revealing cholesterol's impact on mRNA release.

MORPHIS quantifies single-cell morphological responses to treatments and aging, distinguishing compound-specific signatures and aging-related changes in Caco-2, HeLa, and C. elegans cells.

This study develops polymer-modified liposomes (PMLs) for drug delivery, showing size-dependent cargo packing and effective intracellular delivery of various cargoes including siRNA.

This study synthesizes and characterizes pH and temperature responsive lipase-polymer biohybrids, showing increased enzymatic activity and stability compared to native lipases.

The paper shows that neurons have constitutive endolysosomal perforations enabling internalized alpha-synuclein fibrils to induce aggregation, and inhibiting PIKfyve kinase reduces this effect.