Author

Frank Schulz

University of CopenhagenORCID 0000-0002-0118-4388Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Assay:fluorescence / live-cell microscopy· 2 Organism:human· 2 Approach:microscopy & imaging analysis· 2 Assay:bulk RNA-seq· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:cell-cell communication· 1 Approach:deep learning· 1 Research Focus:drug response / drug discovery· 1

Frequent Co-Authors

Nikos S. HatzakisiD· 3 shared Artù BreueriD· 2 shared Georgios BolisiD· 2 shared Georgios KyriakakisiD· 2 shared Marcus Winther DreisleriD· 2 shared Athanasios OikonomouiD· 1 shared Denis Koylyu· 1 shared Emily Winther SørenseniD· 1 shared

Activity by Year

2026-2026 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 34 mutual co-author links

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3 shared papersBiophysics

Nikos S. HatzakisORCID

Mutual co-authors in cluster

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3 papers

Recent·Most cited

Single-Particle Tracking and Positional Phenotyping Reveals Variant-Specific Early Checkpoints in SARS-CoV-2 Cell Entry

Frank Schulz, Marcus Winther Dreisler, Denis Koylyu, Julián Valero, Mette Galsgaard Malle, Laia Civit, Jørgen Kjems, Nikos S. Hatzakis

This study uses single-particle tracking to compare early entry checkpoints of SARS-CoV-2 G614 and BA.5 variants, revealing variant-specific differences in binding and internalization.

ACS Applied Bio Materials · Aug 3, 2026Peer-reviewedBiophysics

Tuning siRNA packing order in lipid nanoparticles modulates oligonucleotide functional delivery

Artù Breuer, Georgios Kyriakakis, Marcus Winther Dreisler, Frank Schulz, Georgios Bolis, Stavroula Margaritaki, Vasilis Papageorgiou, Ntaniela Spacho, Nikos S Hatzakis

This study shows that tuning siRNA packing order in lipid nanoparticles improves functional delivery by enhancing silencing potency through less compact packing.

bioRxiv · May 22, 2026 · PreprintBiophysics

Rapid and reliable quantification of cytosolic mRNA escape (RNASCAPE)

Frank Schulz, Emily Winther Sørensen, Steen W.B. Bender, Artù Breuer, Georgios Kyriakakis, Jacob Kæstel‐Hansen, Georgios Bolis, Athanasios Oikonomou, Konstantinos Tsolakidis, Stefanos Arampatzis, Guangjun Nie, Nikos S. Hatzakis

RNASCAPE quantifies mRNA cytosolic escape using deep learning, achieving 78% accuracy with three timepoints and LNP parameters, revealing cholesterol's impact on mRNA release.

bioRxiv · Apr 11, 2026 · PreprintBiophysics