Mdig shapes 3D chromatin architecture of immune checkpoint genes and limits metastasis of triple negative breast cancer cells
Ziwei WANG, Ziqi Liu, Chitra Thakur, Yiran Qiu, Jun Wang, Mehdi Damaghi, John D. Haley, Fei Chen
This study identifies mdig as a chromatin-topology regulator that suppresses immune-checkpoint activation and metastasis in triple-negative breast cancer by maintaining 3D chromatin architecture.
bioRxiv · Dec 25, 2025 · PreprintCancer Biology