Mehdi Damaghi

Acid Stress-induced plasma membrane ceramide arises from lysosome-plasma membrane fusion

The paper identifies a lysosome-to-plasma membrane pathway for stress-induced plasma membrane ceramide generation, showing lysosomal ceramide is transferred to the plasma membrane under acidic stress.

Neutral Sphingomyelinase-2 Restrains TAZ to Suppress Breast Tumor Growth

This study identifies nSMase2 as a metabolic tumor suppressor in breast cancer by restraining TAZ and inhibiting tumorigenesis.

Metabolic plasticity enables cancer adaptation to acidic tumor ecosystems

This study shows cancer cells adapt to acidic tumor environments through sphingolipid metabolic plasticity, revealing that targeting metabolic flexibility, not individual pathways, may be more effective.

Mdig shapes 3D chromatin architecture of immune checkpoint genes and limits metastasis of triple negative breast cancer cells

This study identifies mdig as a chromatin-topology regulator that suppresses immune-checkpoint activation and metastasis in triple-negative breast cancer by maintaining 3D chromatin architecture.

Metabolic plasticity increases evolvability and drives persistence to PARP inhibitor in ovarian cancer

Ovarian cancer cells exploit metabolic plasticity to increase their evolvability to persist PARP inhibitor treatment.

Eco-evolutionary Guided Pathomic Analysis to Predict DCIS Upstaging

This study uses ecological analysis of hypoxia and acidosis biomarkers to improve prediction of DCIS upstaging by identifying habitat-based metabolic phenotypes and spatial niches.

Human and bats genome robustness under COSMIC mutational signatures

The paper develops a mutation simulator to assess genome robustness under COSMIC mutational signatures, finding higher resilience in human and bat genomes to APOBEC-related mutations.

Dynamics of fibril collagen remodeling by tumor cells using individual cell-based mathematical modeling

The paper uses a cell-based model to study how tumor cells remodel collagen fibrils in the extracellular matrix and identify patterns associated with tumor behavior.