Author

Yen-Yen Li

Structural Genomics ConsortiumORCID 0009-0002-5733-598XUnclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Biochemistry· 1 Molecular Biology· 1

Signature Assays, Organisms & Methods

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Research Focus:drug response / drug discovery· 1 Approach:experimental assay· 1 Organism:human· 1 Approach:machine learning (classical)· 1 Research Focus:protein folding & dynamics· 1 Assay:structural biology· 1

Frequent Co-Authors

Aiping DongiD· 2 shared Alma Seitova· 2 shared Yanjun LiiD· 2 shared A.M. EdwardsiD· 1 shared Albina Bolotokova· 1 shared Anthony D. KeefeiD· 1 shared Ashley HutchinsoniD· 1 shared Bryan J. FraseriD· 1 shared

Activity by Year

2023-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 33 mutual co-author links

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2 shared papersBiochemistry

Aiping DongORCID

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2 papers

Recent·Most cited

BiochemistryNature CommunicationsPeer-reviewedMay 10, 2025

Structural basis of TMPRSS11D specificity and autocleavage activation

Bryan J. Fraser, Ryan P. Wilson, Sára Ferková…·C.H. Arrowsmith

The paper determines the structural basis of TMPRSS11D autocleavage activation and shows that nafamostat mesylate is cleaved by TMPRSS11D, reducing its efficacy as a protease inhibitor.

10 citations

humanstructural biology

𝕏 PostBluesky

Molecular BiologyJournal of Medicinal ChemistryPeer-reviewedNov 23, 2023

Discovery of a first-in-class small molecule ligand for WDR91 using DNA-encoded chemical library selection followed by machine learning

Shabbir Ahmad, Jin Bao Xu, Jianwen A. Feng…·Levon Halabelian

The paper identifies a first-in-class small molecule ligand for WDR91 using DNA-encoded chemical library selection and machine learning, leading to the discovery of covalent analogs and structural insights.

22 citations

machine learning (classical)drug response / drug discovery

𝕏 PostBluesky