Author

Alma Seitova

University of Toronto

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 2 Molecular Biology· 1

Signature Assays, Organisms & Methods

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Research Focus:drug response / drug discovery· 2 Approach:experimental assay· 2 Organism:human· 2 Approach:machine learning (classical)· 1 Research Focus:protein folding & dynamics· 1 Assay:structural biology· 1

Frequent Co-Authors

Yanjun LiiD· 3 shared Aiping DongiD· 2 shared Hong ZengiD· 2 shared Levon HalabelianiD· 2 shared Yen-Yen LiiD· 2 shared A.M. EdwardsiD· 1 shared Albina Bolotokova· 1 shared Anthony D. KeefeiD· 1 shared

Activity by Year

2023-2025 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 35 mutual co-author links

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3 shared papersBiochemistry

Yanjun LiORCID

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Author profile →

3 papers

Recent·Most cited

Structural basis of TMPRSS11D specificity and autocleavage activation

Bryan J. Fraser, Ryan P. Wilson, Sára Ferková, Olzhas Ilyassov, Jackie Lac, Aiping Dong, Yen-Yen Li, Alma Seitova, Yanjun Li, Zahra Hejazi, Tristan M. G. Kenney, Linda Z. Penn, A.M. Edwards, Richard Leduc, Pierre‐Luc Boudreault, , C.H. Arrowsmith

The paper determines the structural basis of TMPRSS11D autocleavage activation and shows that nafamostat mesylate is cleaved by TMPRSS11D, reducing its efficacy as a protease inhibitor.

Nature Communications · May 10, 2025Peer-reviewedBiochemistry

Kinetic characterization of three human DExD/H-box RNA helicases

Fengling Li, U Hang Chan, Julia Garcia Perez, Hong Zeng, Irene Chau, Yanjun Li, Alma Seitova, Levon Halabelian

This study develops a bioluminescence-based assay to kinetically characterize three human RNA helicases and establishes a high-throughput method for inhibitor discovery.

bioRxiv · Feb 7, 2025 · PreprintBiochemistry

Discovery of a first-in-class small molecule ligand for WDR91 using DNA-encoded chemical library selection followed by machine learning

Shabbir Ahmad, Jin Bao Xu, Jianwen A. Feng, Ashley Hutchinson, Hong Zeng, Pegah Ghiabi, Aiping Dong, Paolo A. Centrella, Matthew Clark, Marie-Aude Guié, John P. Guilinger, Anthony D. Keefe, Ying Zhang, Thomas Cerruti, John W. Cuozzo, , Levon Halabelian

The paper identifies a first-in-class small molecule ligand for WDR91 using DNA-encoded chemical library selection and machine learning, leading to the discovery of covalent analogs and structural insights.

Journal of Medicinal Chemistry · Nov 23, 2023Peer-reviewedMolecular Biology