High-throughput screening for class I peptide MHC binding via yeast surface display
Patrick V. Holec, Kathryn C. Breuckman, Owen K. Leddy, Forest M. White, Bryan D. Bryson, Michael E. Birnbaum
This paper introduces a yeast surface display pipeline to screen for class I peptide MHC binders across multiple alleles and applies it to pathogen proteomes to identify potential T cell antigens.
Proceedings of the National Academy of Sciences · Nov 20, 2025Peer-reviewedImmunology