Patrick V. Holec

The paper identifies bottlenecks in MHC-I antigen presentation by Mtb, showing that only a small fraction of predicted binders are actually presented, and develops computational models to improve prediction.

The paper introduces a scalable TCR synthesis and screening method, TCRAFT, to map antigen reactivity in vitiligo and pancreatic ductal adenocarcinoma.

This paper introduces a yeast surface display pipeline to screen for class I peptide MHC binders across multiple alleles and applies it to pathogen proteomes to identify potential T cell antigens.