Author

Trevor Kramer

Relay Therapeutics (United States)ORCID 0009-0002-5932-7406Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Biochemistry· 1 Biophysics· 1

Signature Assays, Organisms & Methods

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Research Focus:drug response / drug discovery· 2 Approach:experimental assay· 2 Approach:machine learning (classical)· 2 Assay:protein structure· 2 Research Focus:database / resource· 1 Approach:deep learning· 1 Organism:human· 1 Approach:simulation· 1

Frequent Co-Authors

Brian B. GoldmaniD· 2 shared Patrick RileyiD· 2 shared A. M. EdwardsiD· 1 shared Adam R. RensloiD· 1 shared Aiping DongiD· 1 shared Alan AshworthiD· 1 shared Albina Bolotokova· 1 shared Aliakbar Khalili Yazdi· 1 shared

Activity by Year

2024-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 33 mutual co-author links

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2 shared papersBiophysics

Brian B. GoldmanORCID

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2 papers

Recent·Most cited

BiophysicsScience AdvancesPeer-reviewedMay 28, 2025

✦ In-depth digest

Extensive exploration of structure activity relationships for the SARS-CoV-2 macrodomain from shape-based fragment merging and active learning

G. J. Correy, Moira M. Rachman, Takaya Togo…·James S. Fraser

Shape-based fragment merging (FrankenROCS) with Thompson sampling over 22 billion molecules found neutral SARS-CoV-2 macrodomain inhibitors; analogs reached single-digit micromolar IC50, backed by 137 crystal structures.

28 citationstop 1%

virusprotein structure

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BiochemistryJournal of Medicinal ChemistryPeer-reviewedNov 4, 2024

A resource to enable chemical biology and drug discovery of WDR Proteins

Suzanne Z. Ackloo, Fengling Li, Magda Szewczyk…·C. H. Arrowsmith

The paper develops a resource for discovering ligands for WDR proteins using experimental and computational methods, leading to the identification of drug-like ligands for 9 out of 20 targets.

28 citations

humanprotein structure

𝕏 PostBluesky