PhysiologyCardiovascular ResearchPeer-reviewed
Long-term mavacamten exposure reduces force and sarcomere density in a hiPSC model of hypertrophic cardiomyopathy
Marianna Langione, Lucrezia Giammarino, Roberto Semeraro…·Josè Manuel Pioner
This study examines the long-term effects of mavacamten on sarcomere structure and function in hiPSC-derived cardiomyocytes from HCM patients, finding a biphasic reduction in force and structural remodeling.
DOI 10.1093/cvr/cvag159