Dengue viruses serotypes 2 and 4 exhibit distinct infection kinetics and modulation of anti-viral immune responses in human tonsil histocultures
Rafael Fenutría, Laura Espinar‐Barranco, Rebecca E. Hamlin, Maris S. Wilkins, Danielle Novillo, Eva Chebishev, Dabeiba Bernal‐Rubio, Zain Khalil, Ana Silvia Gonzalez-Reiche, Harm van Bakel, Victoria Zyulina, Ana Fernández-Sesma
This study compares DENV-2 and DENV-4 infection kinetics and immune responses in human tonsil histocultures, showing DENV-4 replicates faster and activates innate immunity more strongly.
bioRxiv · May 10, 2026 · PreprintMicrobiology