Harm van Bakel

MDL-001: an Oral, Direct-Acting Broad-Spectrum Antiviral for Influenza-Like Illness (ILI) and Chronic Hepatitis In Vivo

This paper evaluates MDL-001, a broad-spectrum antiviral, showing potent in vitro and in vivo activity against influenza, RSV, SARS-CoV-2, and hepatitis B/C/D viruses, with improved efficacy compared to existing treatments.

A designed overlapping variant immunogen pool elicits broad sarbecovirus neutralization

This paper designs an overlapping variant immunogen pool that elicits broad neutralization against SARS-CoV-2 variants and a chimeric SARS-CoV-1 virus.

Coronavirus protein interaction mapping in bat and human cells identifies molecular and genetic switches for immune evasion and replication

Dengue viruses serotypes 2 and 4 exhibit distinct infection kinetics and modulation of anti-viral immune responses in human tonsil histocultures

This study compares DENV-2 and DENV-4 infection kinetics and immune responses in human tonsil histocultures, showing DENV-4 replicates faster and activates innate immunity more strongly.

Prophage-encoded methyltransferase drives adaptation of community-acquired methicillin-resistant Staphylococcus aureus

This study identifies a prophage-encoded methyltransferase, pamA, that enhances virulence in CA-MRSA by epigenetically upregulating fnbA, promoting biofilm formation and abscess size.

SARS-CoV-2 Omicron Envelope T9I adaptation confers resistance to autophagy

The paper shows that the T9I mutation in the SARS-CoV-2 E protein confers autophagy resistance in Omicron variants, contributing to their spread.

Dissecting human monoclonal antibody responses from mRNA- and protein-based XBB.1.5 COVID-19 monovalent vaccines

This study evaluates monoclonal antibody responses to XBB.1.5 vaccines by analyzing plasmablasts from vaccinated individuals and characterizing their binding and neutralization properties against SARS-CoV-2 variants.

Unraveling SARS-CoV-2 Host-Response Heterogeneity through Longitudinal Molecular Subtyping

This study identifies immune subtypes in hospitalized COVID-19 patients linked to clinical outcomes and long COVID risk through longitudinal multi-omics analysis.

Integrated transcriptomic analysis of human induced pluripotent stem cell-derived osteogenic differentiation reveals a regulatory role of KLF16

The paper identifies KLF16 as an inhibitory regulator of osteogenic differentiation through transcriptomic analysis of human iPSC-derived cells and in vivo validation.

Outbreak of Highly Pathogenic Avian Influenza H5N1 in New England Seals

The paper reports an outbreak of H5N1 in New England seals, linking it to a second wave of H5N1 in wild birds and identifying genetic differences between avian and mammalian infections.

Single-cell analysis identifies a key role for Hhip in murine coronal suture development

The paper uses single-cell RNA-seq to identify Hhip's role in murine coronal suture development, showing its necessity for maintaining suture mesenchyme and osteogenic fronts.

SARS-CoV-2 spread across the Colombian-Venezuelan border

The paper reports SARS-CoV-2 genomic data from Venezuela and finds similarities with Colombian and Brazilian lineages, suggesting cross-border transmission despite containment measures.

Chromatiblock: scalable whole-genome visual-ization of structural differences in prokaryotes

Chromatiblock visualizes syntenic blocks across bacterial genomes to show structural differences.

Epigenomic and functional characterization of a core DNA methyltransferase in the human pathogen Clostridium difficile

This study characterizes the epigenome of C. difficile and identifies a conserved DNA methyltransferase that impacts sporulation and other biological processes.