Author

Cristal Aquino

Howard Hughes Medical InstituteORCID 0009-0002-6187-2403Unclaimed ORCID profile · follow to get notified of new preprints

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Molecular Biology· 1

Signature Assays, Organisms & Methods

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Research Focus:benchmarking· 1 Assay:CRISPR screen· 1 Approach:machine learning (classical)· 1

Frequent Co-Authors

Akosua BusiaiD· 1 shared Cynthia I. TerraceiD· 1 shared David F. SavageiD· 1 shared Hunter M. NisonoffiD· 1 shared Jennifer ListgarteniD· 1 shared Luke M. OltroggeiD· 1 shared Maria LukarskaiD· 1 shared Shineui KimiD· 1 shared

Activity by Year

2026-2026 · peak 1/yr

Co-Author Collaboration Network

9 top collaborators · 36 mutual co-author links

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1 shared paperMolecular Biology

Akosua BusiaORCID

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1 paper

Recent·Most cited

Molecular BiologybioRxivPreprintJul 22, 2026

Activity and specificity trade-offs in adenine base editors

Maria Lukarska, Luke M. Oltrogge, Hunter M. Nisonoff…·David F. Savage

This study investigates the trade-off between activity and specificity in adenine base editors using machine learning and high-throughput screening, finding that activity is the primary determinant of editing outcomes.

DOI 10.64898/2026.07.20.739671

CRISPR screenmachine learning (classical)

𝕏 PostBluesky