Author

Shineui Kim

Howard Hughes Medical InstituteORCID 0000-0002-8174-8963Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

Click to filter author papers

Molecular Biology· 2

Signature Assays, Organisms & Methods

Click to filter · or open tag

Research Focus:benchmarking· 1 Assay:CRISPR screen· 1 Approach:experimental assay· 1 Approach:machine learning (classical)· 1 Research Focus:protein design· 1

Frequent Co-Authors

David F. SavageiD· 2 shared Maria LukarskaiD· 2 shared Akosua BusiaiD· 1 shared Arik ShamsiD· 1 shared Benjamin L. Oakes· 1 shared Brett T. Staahl· 1 shared Christof FellmanniD· 1 shared Cristal AquinoiD· 1 shared

Activity by Year

2021-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 29 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

2 shared papersMolecular Biology

David F. SavageORCID

Mutual co-authors in cluster

Author profile →

2 papers

Recent·Most cited

Activity and specificity trade-offs in adenine base editors

Maria Lukarska, Luke M. Oltrogge, Hunter M. Nisonoff, Yaeko Long, Cynthia I. Terrace, Akosua Busia, Cristal Aquino, Shineui Kim, Jennifer Listgarten, David F. Savage

This study investigates the trade-off between activity and specificity in adenine base editors using machine learning and high-throughput screening, finding that activity is the primary determinant of editing outcomes.

bioRxiv · Jul 22, 2026 · PreprintMolecular Biology

Comprehensive deletion landscape of CRISPR-Cas9 identifies minimal RNA-guided DNA-binding modules

Arik Shams, Sean A. Higgins, Christof Fellmann, Thomas G. Laughlin, Benjamin L. Oakes, Rachel Lew, Shineui Kim, Maria Lukarska, Madeline L. Arnold, Brett T. Staahl, Jennifer A. Doudna, David F. Savage

The paper uses a genetic minimization technique to identify minimal DNA-binding modules in Cas9, showing that large domain deletions can retain function.

Nature Communications · Sep 27, 2021Peer-reviewedMolecular Biology