Maria Lukarska

This study investigates the trade-off between activity and specificity in adenine base editors using machine learning and high-throughput screening, finding that activity is the primary determinant of editing outcomes.

This study reveals the molecular mechanisms of cap-snatching by influenza polymerase using cryo-EM structures of FluPol bound to Pol II and DSIF.

The paper introduces SABER, a method to efficiently map tolerated deletions in SaCas9, enabling the design of minimal CRISPRi effectors.

The paper uses a genetic minimization technique to identify minimal DNA-binding modules in Cas9, showing that large domain deletions can retain function.