Luke M. Oltrogge

The paper determines the structure of the DAB1 complex from Thermocrinis albus using cryo-EM, revealing how proton translocation couples to active-site remodeling for directional CO2 hydration.

This study investigates the trade-off between activity and specificity in adenine base editors using machine learning and high-throughput screening, finding that activity is the primary determinant of editing outcomes.

This paper uses cryoET to determine Rubisco polymerization constants in α-carboxysomes by converting tomography data into binding curves.

The paper introduces SABER, a method to efficiently map tolerated deletions in SaCas9, enabling the design of minimal CRISPRi effectors.

This study identifies conserved and repetitive motifs in CsoS2 that drive α-carboxysome assembly and demonstrates in vitro reconstitution of carboxysomes.

The paper re-examines tradeoffs between Rubisco kinetic parameters using data from ~300 organisms, finding that most correlations are attenuated and only one tradeoff model remains.

The paper identifies a novel class of inorganic carbon transporters in chemoautotrophic bacteria through a genome-wide screen and characterizes their function as energy-coupled bicarbonate pumps.